DRAFT 0.1 — In development · Not validated for clinical use

CLINICAL GUIDE

ImmunoTox

Immunotherapy toxicity protocols

Draft 0.1, October 2026 · Editor: Dr. Ali Chamseddine, MD, PhD

A guide to the recognition and management of immune-related adverse events from immune checkpoint inhibitors (anti-PD-1, anti-PD-L1, anti-CTLA-4 and anti-LAG-3), for oncologists, emergency physicians, ward doctors and nurses.

Each chapter opens with a Quick action box for the first clinician who sees the patient, then grading, work-up, management by grade, rechallenge and the points where the guidelines differ.

Chapters